Le 12 avril/April&nbsp;2019

	Willow Biosciences Inc., the issuer resulting from a Fundamental Change of Makena Resources Inc., has been approved for listing.

	Listing and disclosure documents will be available at&nbsp;www.thecse.com&nbsp;on the trading date.

	Willow Biosciences&nbsp;are pioneers in the biotechnology sector and have developed the only fully-integrated synthetic biology solution for opioid biosynthesis. We are now leveraging our unique design-build process to the biosynthesis of&nbsp;cannabinoids.

	________________________

	Willow Biosciences Inc., l'émetteur résultant d'un changement fondamental de Makena Resources Inc., a été approuvée pour l'inscription.

	Les documents de cotation et d'information seront disponibles sur www.thecse.com à la date de négociation.

	Willow Biosciences est un pionnier du secteur des biotechnologies et a développé la seule solution de biologie synthétique totalement intégrée pour la biosynthèse des opioïdes. Nous tirons maintenant parti de notre processus unique de conception-construction pour la biosynthèse des cannabinoïdes.
<table border="1" cellpadding="1" cellspacing="1" >
<tbody>
<tr>
<td >
				Issuer/Émetteur:</td>
<td >
				Willow Biosciences Inc.</td>
</tr>
<tr>
<td >
				Security Type/Titre:</td>
<td >
				Common&nbsp;Shares/Actions&nbsp;ordinaires</td>
</tr>
<tr>
<td >
				Symbol(s)/Symbole(s):</td>
<td >
				WLLW</td>
</tr>
<tr>
<td >
				Number of securities issued and outstanding/&nbsp;Titres&nbsp;émis&nbsp;et en circulation:</td>
<td >
				1 708 500 005</td>
</tr>
<tr>
<td >
				Number of Securities reserved for issuance/&nbsp;Titres&nbsp;réservés&nbsp;pour&nbsp;émission:</td>
<td >
				882 362 026</td>
</tr>
<tr>
<td >
				CSE Sector/Catégorie:</td>
<td >
				Life Sciences/Sciences biologiques</td>
</tr>
<tr>
<td >
				CUSIP/:</td>
<td >
				97111B 10 7</td>
</tr>
<tr>
<td >
				ISIN:</td>
<td >
				CA 97111B 10 7 6</td>
</tr>
<tr>
<td >
				Old/Vieux CUSIP &amp; ISIN:</td>
<td >
				56087W206/CA56087W2067</td>
</tr>
<tr>
<td >
				Boardlot/Quotité:</td>
<td >
				1,000</td>
</tr>
<tr>
<td >
				Trading&nbsp;Currency/Monnaie&nbsp;de&nbsp;négociation:</td>
<td >
				CDN$/$CDN</td>
</tr>
<tr>
<td >
				Trading Date/Date de&nbsp;negociation:</td>
<td >
				Le 15&nbsp;avril/April&nbsp;2019</td>
</tr>
<tr>
<td >
				Other Exchanges/Autres&nbsp;marches:</td>
<td >
				N/A</td>
</tr>
<tr>
<td >
				Fiscal Year&nbsp;end /Clôture&nbsp;de&nbsp;l'exercice&nbsp;financier:</td>
<td >
				Le 30 juin/June</td>
</tr>
<tr>
<td >
				Transfer Agent/Agent des&nbsp;transferts:</td>
<td >
				Odyssey Trust Company</td>
</tr>
</tbody>
</table>

	The Exchange is accepting Market Maker applications for WLLW. Please email:&nbsp;<a href="mailto:Trading@theCSE.com" >Trading@theCSE.com</a>

	If you have any questions or require further information please contact Listings at (416) 367-7340 or E-mail:&nbsp;<a href="mailto:Listings@thecse.com" >Listings@thecse.com</a>

	Pour toute question, pour obtenir de l’information supplémentaire veuillez communiquer avec le service des inscriptions au 416 367-7340 ou par courriel à l’adresse:&nbsp;&nbsp;<a href="mailto:Listings@thecse.com" >Listings@thecse.com</a>

Willow Biosciences Inc.

2019-0411 – Fundamental Change - Makena Resources Inc./Willow Biosciences Inc.

CSE25™

CSE Composite Index®

In this series, we delve deep into the experiences of CSE listed companies, exploring their past successes and future opportunities.

CSE Issuer Spotlight

**Follow us** for the **latest news** from the CSE

 The CSE provides a modern and efficient alternative for companies looking to access the Canadian public capital markets.

The Canadian Securities Exchange (CSE)

Learn how we streamline issuer regulation through enhanced disclosure, practical and effective regulatory oversight, and modern technology.

Listing on the CSE

Learn more about the companies we list and how to get started trading on the CSE.

Investing in Listed Companies

Learn how we lower costs, reduce complexity, and provide market making opportunities for the dealer community.

Trading on the CSE

Whether you’re an investor, business leader, or simply looking to learn more, start your journey with the CSE here.

Get Started

From announcements and market updates to in-depth interviews with company leaders - stay informed with the latest from the CSE.

Latest from the CSE

Discover newly listed companies on the CSE through our series of bite-sized interviews with company leaders.

Get to know our latest listings

Listed Company News

Market Activity

List with the CSE

Find a home for your next big idea.

Frequently Asked Questions

How does being listed on the CSE affect me as a shareholder?

Where do I get information and trade CSE listed securities?

Where can I find an RSS feed for listed company news?

Where is the CSE recognized?

Upcoming Events

join the list

Join our mailing list to receive buy-in notifications

The CSE provides a superior exchange experience by investing in our customers’ success with innovation, dedication, and passion.

Where innovation, passion, and trust intersect

We strive to be the most innovative exchange in Canada. We aim to offer unlimited global access and a customized client-centric experience while delivering the lowest cost of public capital. 

We are Canada's entrepreneurial exchange

The most searched CSE listed companies on thecse.com

Recent Quotes

Get the latest regulatory announcements from the CSE concerning its Listings Policies, Trading Rules and functionality and other important industry developments.

Notices

Get the latest information about new CSE listings, the appointment of Market Makers, market events, and other news.

Bulletins

Stay informed with CSE listed company news, providing transparency and accountability to shareholders and the public.

Company News

Stay Informed

The **total volume** traded on the CSE today is

Connect with our professionals and listing experts at industry events and conferences.

Meet us at upcoming events

The Innovation Centre

Summit on Responsible Investment (SoRI)

Quebec City view for ThE Mining Investment Event image

Centre des congrès de Québec

THE Mining Investment EVENT

Vancouver city image for Web Summit event

Vancouver Convention Centre

Web Summit Vancouver

Metro Toronto Convention Centre

PDAC 2026

Vancouver Resource Investment Conference (VRIC)

Park Hyatt Zurich

Precious Metals Summit Zurich

La Valle Coastal Club

Torrey Hills Capital Resource Executives Conference

JW Marriott Washington, DC

STA 92nd Annual Market Structure Conference

Arcadian Court

Planet MicroCap Showcase: TORONTO 2025

Calgary Petroleum Club

TAKESTOCK – Calgary Investor Forum

Beaver Creek Resort

Precious Metals Summit Beaver Creek

Halifax Marriott Harbourfront Hotel

Going Public and Raising Capital in Canada

Sheraton Centre Toronto Hotel

Red Cloud Fall Mining Showcase 2025

Saxon Woods Park

Wall Street Rides FAR

The St. Regis Toronto

ArcStone-Kingswood Growth Summit 2025

OTC Markets Center

The Global Markets Forum

Fairmont Château Laurier

CSTA Annual Conference 2025

Rixos Tersane Istanbul

The 64th WFE General Assembly & Annual Meeting

Sherbourne Common

Bay Street Rides FAR

The Omni King Edward Hotel

PCMA Conference